Cataracts may occur due to a variety of causes such as genetic, diabetes, PRA and age.
The ideal treatment for cataracts is surgical removal via phacofragmentation. This however may not be an option due to various reasons such as medical, financial or old age. Furthermore, cataracts secondary to retinal degeneration such as PRA are not removed. In these cases, medical management will be required.
All cataracts generate a degree of lens-induced uveitis (LIU). The change in lens protein that occurs as a cataract develops appears to make it more susceptible to leakage out of the lens capsule and this incites an inflammatory reaction. Where a cataract progresses rapidly, for example with diabetes, LIU seems to be more severe. LIU needs to be treated in order to prevent painful sequelae such as lens luxation and glaucoma. The treatment for these conditions is generally eye removal or intrascleral prosthesis as topical glaucoma medications do not have good efficacy in the long term.
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